Posted on by

🌿🍄 Mixing Amanita with Other Substances

Mixing Amanita with Other Substances: Insights from Science, Herbalism, Seasoned Psychonauts, and Spiritual Practioners. What You Need to Know Before You Try It

Don’t want to read this long article? Watch it on our YouTube Channel. Otherwise, enjoy.

One of the most common questions in Amanita forums is: “Can I mix it with other things?”
The answer is layered.

From a scientific standpoint, Amanita muscaria, regalis, and pantherina act as GABAergic CNS depressants via muscimol.

From an experiential standpoint, spiritual seekers, herbalists, and psychonauts report unique synergies—some supportive, some destabilizing. Let’s break it down.

⏳ First, A Reminder on Onset

Unlike psilocybin or cannabis, Amanita is slow acting.

  • On an empty stomach or with a healthy gut, onset may come in as little as 30 minutes.
  • For those with gut sluggishness, digestive issues, or after a heavy meal, onset may delay 2+ hours.
  • This is critical when mixing—many people combine too early, assuming nothing is happening, and then find themselves overwhelmed when Amanita finally activates.

Patience is part of the medicine.

Amanita is not in a rush. Its spirit works like the moon—slowly waxing into presence. Delayed onset can be frustrating for the mind, but spiritually it’s an invitation to surrender control and trust timing. When you sit in patience, you align with Amanita’s rhythm: not forcing but receiving.

Take this time as an opportunity to journal or reflect.

How long is the onset taking?

Am I entuned with my body enough to recognize shifts and changes?

Do I need to work on my digestive/ gut health?

💡 Want a deeper dive into why digestion, gut health, and fasting matter? Read our post on Amanita & the Gut: Why Diarrhea Happens

🌿 Mixing Amanita with Cannabis

  • Community Reports: Experiences vary widely. Cannabis often dampens Amanita’s dream state. Some say it makes visions vanish, while others report it amplifies dissociation and body load.
  • Synergy: A small amount taken later in the Amanita session may soften the body and help release tension, but starting both together tends to fragment the experience.
  • Science Lens: THC increases dopamine and can overstimulate CB1 receptors, while muscimol enhances GABA-A activity. Together, they can pull you in opposite directions—dream suppression vs dream enhancement.

🍫 Mixing Amanita with Cacao

  • Herbalist View: This is a heart-opening, circulation-enhancing ally. Cacao increases blood flow and adds warmth to Amanita’s cool, lunar energy.
  • Best Use: Ceremonial settings, meditation, or creative work. Many practitioners note this duo helps integrate insights gently without overwhelming the nervous system.

✨ See our ceremony write-up: Cacao Ceremony & Amanita — how these two medicines weave heart and dream together.

🍷 Mixing Amanita with Alcohol

  • Why It’s Strongly Discouraged: Both alcohol and Amanita are CNS depressants. Together, they can induce blackouts, severe disorientation, nausea, and dangerous dissociation.
  • Community Consensus: Nearly every experienced psychonaut agrees: skip this combination. It reduces clarity and can create risky physical scenarios (falls, memory gaps).
  • Spiritual Lens: Alcohol is often called a “spirit thief” in esoteric traditions—it blurs the astral body, leaving gaps where clarity should be. Amanita, on the other hand, heightens awareness of subtle realms and strengthens dream-body coherence. Together, they create chaos: the mushroom tries to build, while alcohol unravels. From a spiritual view, this mix scatters energy and attracts parasitic forces. This is why almost every tradition discourages it.

🌌Mixing Amanita with Psychedelics (Psilocybin, LSD, DMT, etc.)

  • Experiential Insights: Many report that Amanita smooths the vibrational rise of classical psychedelics, allowing the body to stay calm while consciousness expands.
  • Metaphor Used by Psychonauts: Amanita acts like a “brave anchor,” grounding the storm of psilocybin while supporting courage to face shadow material.
  • Science Lens: While muscimol is GABAergic (inhibitory), psilocybin and LSD act on serotonin (5-HT2A agonists). This creates a unique push-pull: sedative grounding + psychedelic stimulation. The result can feel synergistic but requires careful respect.

🧘‍♀️Further Reading:
Explore these differences more in depth with:

🌸 Mixing Amanita with Other Herbs

  • Blue Lotus (Nymphaea caerulea): Often paired for dream enhancement and deeper relaxation. Together, they can amplify oneiric (dreamlike) qualities and support sleep states.
  • Lion’s Mane: Popular in microdosing protocols. Lion’s Mane supports nerve growth factor (NGF) while Amanita modulates GABA. Many believe they work synergistically for long-term brain and nervous system support.
  • Kava/Kratom: Reported but not widely recommended. Kava (another GABAergic) risks compounding sedation; kratom complicates receptor interplay.

🌙 Why Mixing Isn’t Always the Answer

Amanita alone is already a multifaceted entheogen: grounding, visionary, calming, and disorienting. Mixing may mask its teachings or create unpredictable chemistry.
As one psychonaut put it:

“Amanita will show you how to walk with bravery. Adding too much else and you might miss the lesson.”

✨ Closing Thought

If you choose to mix, do so from a place of intention, not escape. Start with Amanita alone first—understand its language. Then, if you decide to pair it, go slow, document, and let your body be your teacher.

“Want to keep exploring? Browse all of our Think Beyond Posts for more insights and practices.”

⚠️ Disclaimer: For educational purposes only. Amanita is not FDA-approved for consumption, and nothing here is medical advice.